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Submitted: 14 Jan 2019
Accepted: 08 Apr 2019
ePublished: 03 May 2019
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Immunopathol Persa. 2019;5(1): e11.
doi: 10.15171/ipp.2019.11
  Abstract View: 491
  PDF Download: 362

Mini-Review

Administration of metformin to increase the efficacy of chemotherapy regimen in cancers; a new look to an old drug

Niloufar Hooshyar 1 ORCID logo, Ramin Tolouian 2 ORCID logo, Behzad Ghasemi 3 ORCID logo, Nafiseh Nowrouzi 3 ORCID logo, Banafsheh Yalameha 4 ORCID logo, Mohammadreza Khosravifarsani 5 * ORCID logo, Parto Nasri 6 ORCID logo

1 Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Medicine, University of Arizona, Tucson, Arizona, USA
3 Faculty of pharmacy, Pécs University, Pecs, Hungary
4 Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
5 Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
6 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
*Correspondence to Mohammadreza Khosravifarsani, Email:drmohammadkhf@gmail. com and Khosravifarsani@med. mui.ac.ir

Abstract

Chemotherapeutic agents are still the major and most common therapy to prevent tumor growth. These drugs have various adverse effects in different organs in addition to systemic effects. Finding more specific and effective drugs or new adjuvant therapeutic substance is needed to improve the success rate. Several studies have proposed the possible mechanisms of anti-neoplastic of metformin, however, its exact mechanism is still obscure. The suggested mechanisms are; alteration in the host metabolic environment after administration of metformin, such as decreases in insulin-dependent stimulation of tumor growth or direct effect on cancer cells, such as the impact on adenosine monophosphate (AMP)-activated protein kinase signaling pathway. Metformin, as an adjuvant therapy, synergistically exerts growth inhibitory effects against cell growth and can induce cell apoptosis in an animal model. Adding metformin to the chemotherapy regimen may reduce resistance and enhance therapeutic efficacy.
Keywords: Chemotherapy, Metformin, Cancer, Tumor, type 2 diabetes, Adjuvant therapy..
 Citation: Hooshyar N, Tolouian R, Ghasemi B, Nowrouzi N, Yalameha B, Khosravifarsani M, et al. Administration of metformin to increase the efficacy of chemotherapy regimen in cancers; a new look to an old drug. Immunopathol Persa. 2019;5(1):e11. DOI:10.15171/ ipp.2019.11.
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