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Submitted: 01 Mar 2019
Accepted: 15 Apr 2019
ePublished: 05 May 2019
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Immunopathol Persa. 2019;5(1): e07.
doi: 10.15171/ipp.2019.07
  Abstract View: 462
  PDF Download: 380

Review

Mechanistic impact of medicinal plants affecting cisplatin-induced nephrotoxicity; an overview

Niloufar Hooshyar 1 ORCID logo, Mehrnoosh Sedighi 2 ORCID logo, Masoomeh Hooshmand 3 ORCID logo, Rohollah Valizadeh 4 ORCID logo, Semko Ebrahimi 5 ORCID logo, Mohammadreza Khosravifarsani 6 * ORCID logo, Behzad Ghasemi 7 ORCID logo, Nafiseh Nowrouzi 7 ORCID logo, Parto Nasri 8 ORCID logo

1 Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran
3 Department of Environmental Engineering, Istanbul Technical University, Istanbul, Turkey
4 Department of Epidemiology, Student Research Committee, School of Public Health, Iran University of Medical science, Tehran, Iran
5 Department of Anesthesiology, Health North gGmbH Klinikverbund Bremen, Hospital left of the Weser (klinkum Links der Weser) (Senator-Weßling-Straße 1; 28277), Bremen, Germany
6 Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
7 Faculty of pharmacy, Pécs University, Pecs, Hungary
8 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
*Correspondence to Mohammadreza Khosravifarsani, Email; drmohammadkhf@gmail. com and Khosravifarsani@med. mui.ac.ir

Abstract

Cisplatin is a powerful chemotherapy drug that is administered to treat a wide range of cancers. However, its clinical use is limited due to kidney damage and the reduction in glomerular filtration rate that occurs in 15% to 30% of patients. Several mechanisms lead to renal dysfunction after cisplatin administration, including direct damage to proximal tubular epithelial cells that causes necrosis and apoptosis. Cisplatin administration is accompanied by the production of reactive oxygen species (ROS), which causes lipid peroxidation, proteins and nucleic acids oxidation, cell membrane degradation, and finally reduction in glomerular filtration. The most prominent effect of cisplatin-induced nephrotoxicity (CIN), which can be progressive, is hypomagnesemia, Fanconi syndrome and anemia. Cisplatin nephrotoxicity is more prominent in individuals who received higher doses of this drug, or in patients who had previous chemotherapy regimen and presence of renal dysfunction. This paper is sought to describe cisplatin nephrotoxicity and the protective role of medicinal plants in preventing the renal toxicity. In this regard, the role of antioxidants will be specifically addressed.
Keywords: Cisplatin, Cisplatininduced nephrotoxicity, Chemotherapy, Medicinal plants
 Citation: Hooshyar N, Sedighi M, Hooshmand M, Valizadeh R, Ebrahimi S, Khosravifarsani MR, et al. Mechanistic impact of medicinal plants affecting cisplatin-induced nephrotoxicity; an overview. Immunopathol Persa. 2019;5(1):e07. DOI: 10.15171/ ipp.2019.07.
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