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Submitted: 11 Aug 2019
Accepted: 09 Dec 2019
ePublished: 07 Jan 2020
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Immunopathol Persa. 2020;6(1): e11.
doi: 10.15171/ipp.2020.11
  Abstract View: 222
  PDF Download: 167

Original

The impact of colchicine in preventing postpericardiotomy syndrome; a double-blind clinical trial study

Navid Reaza Mashayekhi 1 ORCID logo, Alireza Alisaeedi 1 * , Alireza Rostami 2 ORCID logo, Parvin Soltani 3 ORCID logo

1 Department of Cardiology, Arak University of Medical Sciences, Arak, Iran
2 Department of Cardiac Surgery, Arak University of Medical Sciences, Arak, Iran
3 Department of Internal Medicine, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
*Correspondence to Alireza Alisaeedi, Email: dr.alisaeedi@arakmu. ac.ir

Abstract

Introduction: Post-pericardiotomy syndrome is a relatively common complication after open heart surgery. In recent years, colchicine had a good effect on treatment of the pericarditis.

Objectives: This study aimed to study the effect of colchicine to prevent post-pericardiotomy syndrome in patients who had open heart surgery.

Patients and Methods: This double-blind clinical trial study was conducted on 240 patients undergone open heart surgery. Eligible patients were selected by simple sampling and randomly divided into two groups; 120 subjects in the experimental group receive colchicine (1 mg for patients greater than 70 kg and 0.5 mg for patients lower than 70 kg) and 120 subjects in the control group who received the placebo. Patients were followed up regarding the incidence of post-pericardiotomy syndrome after the surgery during hospitalization and in follow up visits in one month and six months after hospital discharges.

Results: In total, the incidence rate of post-pericardiotomy syndrome was 33.7% (81 subjects). A significant difference of post-pericardiotomy syndrome between two groups was seen. We found post-pericardiotomy syndrome in 12.1% (29 patients) of colchicine group versus 21.6% (52 patients) in the placebo group (chi-square test). The incidence rate based on the Kaplan-Meier curve, in the second week to one month after the surgery, was lower in colchicine group while in third to the sixth month it had a constant trend.

Conclusion: Colchicine is effective for prevention the post-pericardiotomy syndrome without any life-threatening complication.

Keywords: Colchicine, Pericarditis, Postpericardiotomy syndrome, Open heart surgery, Cardiopulmonary bypass, Antiinflammatory
Citation: Mashayekhi NR, Alisaeedi A, Rostami A, Soltani P. The impact of colchicine in preventing post-pericardiotomy syndrome; a doubleblind clinical trial study. Immunopathol Persa. 2020;6(1):e11. DOI:10.15171/ ipp.2020.11. 
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