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Submitted: 03 Jan 2019
Accepted: 06 Feb 2019
ePublished: 23 Feb 2019
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Immunopathol Persa. 2019;5(1): e03.
doi: 10.15171/ipp.2019.03
  Abstract View: 719
  PDF Download: 446

Original Article

Association of CDX2 expression and overall survival and clinicopathologic disease manifestations in patients with gastric cancer in Northwest of Iran 

Farideh Akbari 1 ORCID logo, Zohreh Ghoreishi 2 ORCID logo, Mohammad Asghari Jafarabadi 3,4 ORCID logo, Khatereh Rezazadeh 2 ORCID logo, Babak Nejati 1, Ali Esfahani 1 * ORCID logo

1 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3 Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
*Correspondence to Ali Esfahani, Email: ali.sfhn@gmail.com, esfahania@tbzmed.ac.ir

Abstract

Introduction: In the northwest of Iran, gastric cancer is the first and third common form of malignancy in men and women, respectively. Homeobox protein CDX2, was proposed as a prognostic biomarker in gastric cancer.

Objectives: This study aimed to assess the association of CDX2 expression overall survival as well as clinicopathologic variables in patients with gastric cancer.

Materials and Methods: CDX2 expression was examined by the immunohistochemistry method in the formalin-fixed paraffin-embedded surgical specimens of gastric cancer. The association between CDX2 expression and overall survival, stage of the disease, metastasis status, pathology type of the tumor, and serum levels of tumor markers serum levels of tumor markers carcinoembryonic antigen (CEA), cancer antigen 125 (CA-125), cancer antigen 19-9 (CA 19-9) was then evaluated.

Results: Ninety-two patients with primary gastric cancer were recruited. CDX2 expression was positive in 72 (78%) of the subjects. Overall survival was not significantly different between two groups of patients (CDX2 positive versus negative). However, the risk of death was 21% lower in CDX2 positive patients, after adjusting for age and gender (P=0.565). Disease stage and metastasis rate were significantly lower in CDX2 positive patients (P=0.027, and P=0.021, respectively). Additionally, 71% of the CDX2 positive subjects had intestinal pathology type of the disease (P=0.025). Accordingly, a significant lower level of CA19-9 was found in CDX2 positive patients as well (P=0.002).

Conclusion: There was not any significant association between CDX2 expression and overall survival in patients with gastric cancer, although the risk of death was lower in CDX2 positive subjects. However, there was a less invasive pattern of gastric carcinoma in this group of patients. 

Keywords: Gastric cancer, Homeobox protein CDX2, Overall survival, Clinicopathologic characteristics
Citation: Akbari F, Ghoreishi Z, Asghari Jafarabadi M, Rezazadeh K, Nejati B, Esfahani A. Association of CDX2 expression and overall survival and clinicopathologic disease manifestations in patients with gastric cancer in Northwest of Iran. Immunopathol Persa. 2019;5(1):e03. DOI:10.15171/ ipp.2019.03.
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