Submitted: 18 Oct 2017
Accepted: 09 Dec 2017
First published online: 02 Jan 2018
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Immunopathol Persa. 2018;4(1):e12-.
doi: 10.15171/ipp.2018.12
  Abstract View: 416
  PDF Download: 479

Original

Histological and immunohistochemically profiles of renal cell carcinoma in northern Nigeria 

Atanda T. Akinfenwa 1,2 * , Atanda O. Jareenat 1,2, David T. Noah 2

1 Department of Pathology, Bayero University, Kano, Nigeria
2 Department of Pathology, Aminu Kano Teaching Hospital, Kano, Nigeria
Correspondence to Atanda T. Akinfenwa Email: atatanda.pat@buk.edu.ng

Abstract

Introduction: Histologically, renal cell carcinoma (RCC) is classified into predominantly clear cell carcinoma, papillary carcinoma (PC), chromophobe carcinoma, collecting ducts of Bellini carcinoma and Xp11 carcinoma.

Objectives: This study aims to evaluate histological profile and staining patterns of RCC subtypes.

Materials and Method: All cases of RCC histologically diagnosed in the pathology department of a teaching hospital in northern Nigeria in 2015 were stained using a panel of 34ẞE12, CK7, RCC-ma and CD10 antibodies.

Results: Around 23 cases of RCC, at stage III, were diagnosed. Male: Female ratio was 1:1.9 with a mean age of 40±13 years. The tumors comprised of 11 (47.8%), cases of clear cell (CC) carcinoma, 7 (30.4%) cases of PC, 4 (17.4%) cases of chromophobe carcinoma and a case (4.4%) of Xp11.2associated carcinoma. Eighty-eight percent of the CC carcinomas were RCC-ma+, 63% were CD10+ while 50% were CK7+. Seventy-five percent of the PCs were RCC-ma+ and 50% were CD10+. The chromophobe (CP) and the Xp11.2-associated carcinomas were only positive for RCC-ma and CD10. All cases of PCs, chromophobe and Xp11.2 related carcinomas were negative for CK7, and all were 34ẞE12 negative.

Conclusion: In contrast to populations with high incidence of RCC, our patients are predominantly female, younger, presented at higher stages and mostly presented with CC carcinoma.

Citation: Akinfenwa AT, Jareenat AO, Noah DT. Histological and immunohistochemically profiles of renal cell carcinoma in northern Nigeria. Immunopathol Persa. 2018;4(1):e12. DOI: 10.15171/ ipp.2018.12.
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