Immunopathol Persa. 2018;4(1):e09-.
doi: 10.15171/ipp.2018.09
  Abstract View: 701
  PDF Download: 609


Frequency of serum sickness and its related factors in Kurdistan, west of Iran; a 13-year study

Rasoul Nasiri Kalmarzi 1, Zaher Khazaei 2, Sina Zamanei 3, Sajjad Rahimi Pordanjani 4, Ebrahim Ghaderi 5, Elham Goodarzi 6 *

1 Department of Pediatrics of Beast Hospital, Cellular & Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
2 Department of Health and Community Medicine, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran
3 Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
4 Department of Epidemiology and Biostatistics, School of Health, Semnan University of Medical Sciences, Semnan, Iran
5 Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
6 Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
Correspondence to Elham Goodarzi Email:


Introduction: Serum sickness is an acute and self-limiting disease caused by allergic reactions as a result of foreign proteins, injection or allergens. It is diagnosed by fever, lymphadenopathy, rash, gastrointestinal disorders and weakness.

Objectives: The aim of this study was to evaluate the frequency of serum sickness and serum-like sickness in patients hospitalized in Kurdistan province.

Patients and Methods: This is a cross-sectional study. The study included all patients who were hospitalized during 2001 to 2014. Demographic data, etiologic factors, clinical symptoms and laboratory findings using patients’ records were extracted. The data were analyzed using the software Stata 12.

Results: Out of 74 patients 55 (74.3%) were male and 19 (25.7%) were female. The mean age of all patients was 25.13±17.9 years. The average length of hospital stay in patients was 3.48±0.47 days. The mean interval between medication consumption and the onset of symptoms was 7.32±2.44 days. Moreover, the mean interval between taking medication and onset of symptoms is not different among groups (P ˃ 0.05). In the majority of cases, the most affected of body areas were the right buttock (27%) and left buttock (25.7%), respectively. In this study, most cases of serum sicknesses (66.2%) are caused by medication administration. Of them, cefixime and penicillin (2.7%) were the most common medications responsible for this disease. Other causes were included amoxicillin/ clavulanic acid, diclofenac, dexamethasone and amoxicillin (1.4%).

Conclusion: Drugs are a common cause of serum sickness which is generally started 7 to 14 days after consumption. In most patients with mild disease, drug discontinuation is the choice treatment.

Citation: Nasiri Kalmarzi R, Khazaei Z, Zamanei S, Rahimi Pordanjani S, Ghaderi E, Goodarzi E.  Frequency of serum sickness and its related factors in Kurdistan, west of Iran; a 13-year study. Immunopathol Persa. 2018;4(1):e09.
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