Submitted: 10 Apr 2019
Accepted: 20 Jun 2019
First published online: 14 Jul 2019
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Immunopathol Persa. 2019;5(2):e16-e16.
doi: 10.15171/ipp.2019.16
  Abstract View: 223
  PDF Download: 221

Mini-Review

Lung cancer risk and the inhibitors of angiotensinconverting enzyme: A mini-review of recent evidence

Masoumeh Asgharpour 1 ORCiD, Mohammad Ebrahimi Kalan 2 ORCiD, Seyed Hadi Mirhashemi 3, Amirhesam Alirezaei 4 * ORCiD

1 Department of Nephrology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
2 Department of Epidemiology, Robert Stempel College of Public Health, Florida International University, Miami, FL, USA
3 Department of Surgery, Loghman hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Urology and Nephrology Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Correspondence to Amirhesam Alirezaei, Email: amirhesam124@gmail.com and Email: Aalirezaei@sbmu.ac.ir

Abstract

Angiotensin-converting enzyme inhibitors (ACEIs) are among the most widely prescribed antihypertensive medications. They are indicated in the management of multiple chronic conditions including hypertension, diabetes mellitus and heart failure. ACEIs prevent angiotensin II (Ang II) production and bradykinin catabolism leading to vasodilation and reduction of arterial blood pressure. Recently, the role of the reninangiotensin system (RAS) inhibitors has become the subject of scrutiny in the treatment of cancer metastasis. The administration of ACEIs, however, has been described to be accompanying with carcinogenic effects.
Citation: Asgharpour M, Ebrahimi Kalan M, Mirhashemi SH, Alirezaei A. Lung cancer risk and the inhibitors of angiotensinconverting enzyme: A minireview of recent evidence. Immunopathol Persa. 2019;5(2):e16. DOI:10.15171/ ipp.2019.16.
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