Submitted: 20 Mar 2019
Accepted: 11 May 2019
First published online: 15 Jun 2019
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Immunopathol Persa. 2019;5(2):e21-e21.
doi: 10.15171/ipp.2019.21
  Abstract View: 111
  PDF Download: 207

Original Article

The protective effects of Ocimum basilicum extract against gentamicin-induced nephrotoxicity in male rats; an anti-inflammatory, anti-oxidative and antiapoptotic action

Hassan Askari 1 ORCiD, Fatemeh Zeinali 2, Hamed Haghi-Aminjan 3, Seyed Mehdi Hafizi 4, Amirhesam Alirezaei 5 * ORCiD

1 Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Biology, Tehran University, Tehran, Iran
3 Drug and Advanced Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
4 Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Clinical Research and Development Center, Shahid Modarres Hospital, Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Correspondence to Amirhesam Alirezaei, Email: Email: amirhesam124@gmail.com

Abstract

Introduction: Some studies are in favor of protective and anti-inflammatory effects of Ocimum basilicum (OB) against renal failure.

Objectives: The aim of this study was to explore the protective effects of OB extract against gentamicin (GM)-induced nephrotoxicity in male rat models of acute kidney injury.

Materials and Methods: Twenty-seven adult male Wistar rats with the weight of 200-250 g were prepared under standard condition (12 h light/dark cycle, 20 to 22°C temperature). In the gentamicin group (GM), the rats were administrated normal saline (5 mL/kg; oral) for four consecutive weeks and then GM (80 mg/kg/d; intraperitoneal) for another one week. In the third (OB-200+ GM) and fourth (OB-800+ GM) groups, the rats were initially treated with OB extract (200 mg/kg and 800 mg/kg respectively; oral) for four consecutive weeks followed by intraperitoneal administration of 80 mg/kg/d GM for another one week. The control group was treated with normal saline (5 mL/kg; oral) for five consecutive weeks. They were sacrificed under deep anesthesia, then plasma and tissue samples were obtained.

Results: Treatment with OB hydro-alcoholic extract decreased BUN, serum Cr, FeNa and the levels of TNF-a and NF-kB and also diminished the rate of apoptosis in renal tubular cells compared to gentamicin group.

Conclusion: Our findings provide comprehensive evidence supporting the beneficial role of OB, a traditional medicinal herb, as a potential therapeutic supplement to prevent the incidence and progression of renal impairment in GM-induced renal toxicity.

Citation: Askari H, Zeinali F, Haghi-Aminjan H, Hafizi SM, Alirezaei A. The protective effects of Ocimum basilicum extract against gentamicin-induced nephrotoxicity in male rats; an anti-inflammatory, antioxidative and anti-apoptotic action. Immunopathol Persa. 2019;5(2):e21. DOI:10.15171/ ipp.2019.21.
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