Immunopathol Persa. 2019;5(1):e09-e09.
doi: 10.15171/ipp.2019.09
  Abstract View: 40
  PDF Download: 73

Original

Anti-inflammatory effects of different statins in rheumatoid arthritis; a randomized double-blind controlled clinical trial

Mansoor Karimifar 1 ORCiD, Mansour Salesi 1, Rasoul Ghasemian 2 * , Mozhgan Karimifar 3, Ziba Farajzadegan 4, Mohammad Gholamnezhad 5

1 H1Department of Rheumatology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Internal Medicine, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
3 Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Community and Preventive Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Internal Medicine, Beheshti Hospital, Yasuj University of Medical Sciences, Yasuj, Iran
*Correspondence to Rasoul Ghasemian; Email Email: Rasoolqasemian@yahoo.com

Abstract

Introduction: Statin family drugs are lipid-lowering agents with anti-inflammatory effects.

Objectives: The aim of our study was to evaluate anti-inflammatory effects of different statins in rheumatoid arthritis patients.

Patients and Methods: Around 161 eligible subjects with rheumatoid arthritis were enrolled. They randomly were divided into three groups. The first group received 40 mg/daily atorvastatin, the second group received 40 mg/daily simvastatin, and the third group received placebo as control for six months. To calculate the disease activity, DAS-28 (Disease Activity Score 28) was used while VAS (visual analog scale) was used to assess the severity of pain in rheumatoid arthritis patients. DAS-28, erythrocyte sedimentation rates (ESR) and lipid profiles were assessed once for the baseline and then after three and six months of intervention. Data was analyzed by SPSS by a P value <0.05 which was set to be significant.

Results: DAS-28 score in months 0, 3 and 6 in atorvastatin, simvastatin and placebo groups was (5.36 ± 1.02, 3.23±1.24 and 2.81±1.13), (5.29±0.87, 2.75±1.16 and 2.57±1.00) and (5.52±0.96, 3.90±1.10 and 3.87±1.52), respectively. Mean of DAS-28 score differences between placebo and atorvastatin groups was 0.6±0.16 (P<0.01); the score differences between simvastatin and placebo was 0.900±0.16 that was significant (P<0.01), however, the score differences was not significant between atorvastatin and simvastatin groups (P=0.261).

Conclusion: Statins decrease inflammation in rheumatoid arthritis patients

Citation: Karimifar M, Salesi M, Ghasemian R, Karimifar M, Farajzadegan Z, Gholamnezhad M. Anti-inflammatory effects of different statins in rheumatoid arthritis; a randomized double-blind controlled clinical trial. Immunopathol Persa. 2019;5(1):e09. doi:10.15171/ipp.2019.09.
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